TOP
ご挨拶
履歴
連絡先
<業務内容>

List of publications

December 1, 2010
Shuichi Hashizume, Ph.D.

1. Horinishi, H., Hashizume, S. and Seguchi, M. (1975) Occurrence of arginyl-tRNA: protein arginyl transferase in baker's yeast. Biochem. Biophys. Res.Commun., 65: 82-88.
2. Horinishi, H., Hashizume, S., Seguchi, M. and Takahashi, K. (1975) Incorporation of methionine by a soluble enzyme system from Escherichia coli. Biochem. Biophys. Res. Commun., 67: 1136-1143.
3. Hashizume, S., Sekiguchi, T. and Nosoh, Y. (1976) Effect of temperature on the viability of Bacillus stearothermophilus. Arch. Microbiol., 107: 75-80.
4. Rashid, M.A. and Hashizume, S. (1982) Electrophoretic extraction-concentrtion of ribonucleic acid from agarose-acrylamide composite gels. Anal. Biochem., 127: 334-339.
5. Hashizume, S., Honjoh, T. and Shoji, M. (1983) Incorporation of glutamic acid into protein by a soluble system. J. Biochem., 93: 1109-1118.
6. Hashizume, S., Kuroda, K. and Murakami, H. (1983) Identification of lactoferrin as an essential growth factor for human lymphocytic cell lines in serum-free medium. Biochim. Biophys. Acta, 763: 377-382.
7. Hashizume, S., Rashid, M.A., Shoji, M. and Kuroda, K. (1984) Electrophoretic extraction-concentration of proteins from polyacrylamide gels under alkaline neutral and acidic conditions. Electrophoresis, 5: 30-34.
8. Hashizume, S., Kuroda, K., Abe, M. and Murakami, H. (1984) Effect of lactoferrin on the growth of adhesive cell lines. in International Symposium on Growth and Differentiation of Cells in Defined Environment, pp. 295-299.
9. Murakami, H., Shimomura, T., Ohashi, H., Hashizume, S., Tokashiki, M., Shinohara, K., Yasumoto, K., Nomoto, K. and Omura, H. (1984) Serum-free stirred culture of human-human hybridoma lines. in International Symposium on Growth and Differentiation of Cells in Defined Environment, pp. 111-116.
10. Hashizume, S. (1985) Incorporation of isoleucine into protein by a soluble fraction from spermatozoa. FEBS Lett., 184: 44-47.
11. Murakami, H., Hashizume, S., Ohashi, H., Shinohara, K., Yasumoto, K., Nomoto, K. and Omura, H. (1985) Human-human hybridomas secreting antibodies specific to human lung carcinoma. In Vitro Cell. Develop. Biol., 21: 593-596.
12. Ohashi, H., Hashizume, S., Murakami, H., Aihara, K., Shinohara, K. and Omura H. (1986) HO-323, a human B-lymphoblastoid cell line useful for making human-human hybridomas. Cell Biol. Intern. Reports, 10: 77-83.
13. Hashizume, S., Murakami, H., Hirose, S., Shirai, T., Shinohara, K. and Omura H. (1986) Human-human hybridomas from lung cancer patients secrete anti-DNA antibodies. Agric. Biol. Chem., 50: 1351-1353.
14. 橋爪秀一 (1986) モノクローナル抗体の生産と応用. 細胞制御工学, 村上浩紀編, 学窓社, pp. 107-122.
15. Hashizume, S., Murakami, H., Kamei, M., Hirose, S., Shirai, T., Yamada, K. and Omura, H. (1986) Specificity of anti-polynucleotide monoclonal antibodies from human-human hybridomas. In Vitro Cell. Develop. Biol., 23: 53-56.
16. 橋爪秀一, 望月克巳, 村上浩紀 (1987) ヒト－ヒトハイブリドーマの無血清培養. 組織培養 13: 17-20.
17. Hashizume, S., Kuroda, K. and Murakami, H. (1987) Cell culture assay of biological activity of lactoferrin and transferrin. Methods Enzymol., 147: 302-314.
18. 橋爪秀一 (1987) 抗核酸ヒト型モノクローナル抗体. 発酵と工業, 45: 883-884.
19. 橋爪秀一, 本庄勉, 黒田和彦, 小路正博 (1987) ゲルからの電気的なタンパク質抽出法. 生化学, 59: 1155-1160.
20. Yano, T., Yasumoto, K., Nagashima, A., Murakami, H., Hashizume, S. and Nomoto, K. (1988) Immunohistological characterization of human monoclonal antibody against lung cancer. J. Surg. Oncol., 39: 108-113.
21. Miyata, M., Hashizume, S., Murakami, H., Yamada, K. and Omura, H. (1988) Characterization and applications of lymphocytic clonal growth factor in human plasma. Cytotechnology, 1: 233-241.
22. Miyata, M., Murakami, H., Hashizume, S., Yamada, K. and Omura, H. (1988) Purification and characterization of lymphocytic clonal growth factor (LCGF) derived from human-human hybridoma SH-76 cells. Cytotechnology, 1: 347-353.
23. 橋爪秀一, 望月克巳, 村上浩紀, 矢野篤次郎, 野本亀久雄, 安元公正 (1988) ヒト型モノクローナル抗体が認識するブタ由来抗原を用いた｢がんの血清診断｣. 第8回腫瘍マーカ研究会記録, 228-229.
24. 橋爪秀一，黒田和彦，亀井優徳 (1988) ヒト型モノクローナル抗体の作製と生産. Nippon Nogeikagaku Kaishi, 62: 1513-1516.
25. Sato, S., Murakami, H., Sugahara, T., Ikegami, T., Yamada, K., Omura, H. and Hashizume, S. (1989) Stimulation of monoclonal antibody production by human-human hybridoma cells with an elevated concentration of potassium or sodium phosphate in serum-free medium. Cytotechnology, 2: 63-67.
26. Hashizume, S., Mochizuki, K., Murakami, H., Yano, T., Yasumoto, K. and Nomoto, K. (1989) Serodiagnosis of cancer, using porcine antigens recognized by human monoclonal antibody, HB4C5. Biotherapy, 1: 109-115.
27. 橋爪秀一, 佐藤進 (1989) ④. 大量培養, 1.浮遊細胞, 無血清細胞培養マニュアル, 大野忠夫･村上浩紀編, 講談社, pp. 175-185.
28. Yamada, K., Ikeda, I., Sugahara, T., Hashizume, S., Shirahata, S. and Murakami, H. (1990) Stimulation of proliferation and immunoglobulin M production by lactoferrin in human-human and mouse-mouse hybridomas cultures in serum-free conditions. Cytotechnology, 3: 123-131.
29. Kamei, M., Hashizume, S., Sugimoto, N., Ozutsumi, K. and Matsuda, M. (1990) Establishment of stable mouse/human-human hybrid cell lines producing large amounts of anti-tetanus human monoclonal antibodies with high neutralizing activity. Eur. J. Epidemiol., 6: 386-397.
30. Hashizume, S., Sato, S., Matsuyama, M., Tamaki, S., Hanada, K., Murakami, H., Yasumoto, K., Nomoto, K., Nakano, K. and Kusakabe, K. (1990) Accumulation of 125I-labelled human monoclonal antibody (HB4C5), specific to lung cancer, into transplanted human lung cancer in nude mouse. in Proceedings of The Second Annual Meeting of Japanese Association for Animal Cell Technology, pp.167-172.
31. Kamei, M., Hashizume, S., Sugimoto, N., Ozutsumi, K. and Matsuda, M. (1990) Stable mouse/human-human hybridomas producing high tetanus toxin-neutralizing human monoclonal antibodies suitable for large scale production. In Proceedings of The Second Annual Meeting of Japanese Association for Animal cell Technology, pp.173-176.
32. Kawahara, H., Yamada, K., Kuroda, K., Hashizume, S., Shirahata, S. and Murakami, H. (1990) Detection and acquisition of class-switch variants from human-human hybridoma HB4C5, using cell sorter. in Proceedings of The Second Annual Meeting of Japanese Association for Animal Cell Technology, pp.205-208.
33. Hashizume, S., Mochizuki, K., Kamei, M., Kuroda, K., Kato, M., Sato, S., Yasumoto, K., Nakahashi, H., Tsuchimoto, K., Muraoka, M., Nomoto, K. and Мurakami, H. (1991) Serodiagnosis of cancer using carboxypeptidase A as an animal antigen recognized by human monoclonal antibody HB4C5. Hum. Antibod. Hybridomas, 2: 51-56.
34. Kato, M., Mochizuki, K., Kuroda, K., Sato, S., Murakami, H., Yasumoto, K., Nomoto, K. and Hashizume, S. (1991) Histone H2B as an antigen recognized by lung cancer-specific human monoclonal antibody HB4C5. Hum. Antibod. Hybridomas, 2: 94-101.
35. Mochizuki, K., Kato, M., Sato, S., Hashizume, S., Murakami, H. and Nomoto, K. (1991) Characterization of human monoclonal antibody HB4C5. Hum. Antibod. Hybridomas, 2: 116-123.
36. Hashizume, S., Kamei, M., Mochizuki, K., Sato, S., Kuroda, K., Kato, M., Yasumoto, K., Nakahashi, H., Hirose, H., Tai, H., Okano, H., Nomoto, K. and Murakami, H. (1991) Serodiagnosis of cancer by using Candida cytochrome c recognized by human monoclonal antibody HB4C5. Hum. Antibod. Hybridomas, 2: 142-147.
37. Hirose, H., Sato, S., Tai, H., Okano, H., Yasumoto, K., Murakami, H., Nomoto K., Matsuyama, M., Tamaki, S. and Hashizume, S. (1991) Detection of lung cancer in clinical specimens using a human monoclonal antibody HB4C5-clone3. Hum. Antibod. Hybridomas, 2: 200-206.
38. 日下部きよ子, 金谷和子, 中野敬子, 玉城成夫，松山誠孝，佐藤進，橋爪秀一 (1991) モノクローナル抗腫瘍抗体の腫瘍内分布と腫瘍壊死. 免疫核医学, 6: 55-59.
39. Yeh, M., Sun, P, Ji, Y., Hashizume, S. and Kamei, M. (1991) The in vitro induction of antibody responses of human lymphocytes and its application to hybridoma production. Acta Biologiae Experimentalis Sinica, 24: 143-151.
40. Yeh, M., Hashizume, S., et al. (1991) 人－小鼠淋巴細胞融合雑交瘤中抗体分泌和人染色体喪失的関係. Chinese J. Cell Biol., 13: 80-83.
41. Kamei, M., Kato, M., Mochizuki, K., Kuroda, K., Sato, S., Hashizume, S., Yasumoto, K., Murakami, H. and Nomoto, K. (1992) Serodiagnosis of cancers by ELISA of anti-histone H2B antibody. Biotherapy, 4: 17-22.
42. 望月克巳, 佐藤進, 橋爪秀一 (1992) ヒト型モノクローナル抗体の生産用培地の開発. Bio Industry, 9: 46-53.
43. Matsuda, M., Kamei, M., Sugimoto, N., Ma, Y. and Hashizume, S. (1992) Characteristics of toxin-neutralization by anti-tetanus human monoclonal antibodies directed against the three functional domains. Eur. J. Epidemiol., 8: 1-8.
44. Sato, S., Hirose, H., Tai, H., Okano, H., Yasumoto, K., Murakami, H., Nomoto K., Matsuyama, M., Tamaki, S. and Hashizume, S. (1992) Examination of lung cancer using a human monoclonal antibody HB4C5-clone 3. in Animal Cell Technology (eds. Murakami H. et al.), pp. 541-525.
45. Kamei, M., Hashizume, S., Sugimoto, N., Ma, Y. and Matsuda, M. (1992) Anti-tetanus human monoclonal antibodies-comparative studies on their protective activity with polyclonal antibody. in Animal Cell Technology (eds. Murakami H. et al.), pp. 541-525.
46. Jiang, Z., Sun, P., Ji, Y., Yeh, M., Kuroda, K., Kamei, M. and Hashizume, S. (1992) The establishment of human anti-tetanus toxoid hybridomas with in vitro immunized human tonsil cells. Acta Biologiae Experimentalis Sinica, 25: 237-242.
47. Yeh, M., Hashizume, S., et al. (1992) Quantitative evaluation of the stability of antibody production by human-mouse hybridoma clones with flow cytometry analysis. Acta Biologiae Experimentalis Sinica, 25: 243-247.
48. 川原浩治, 橋爪秀一 (1992) ヒトリンパ球の培養とヒト型ハイブリドーマの作成. 動物細胞培養技術, 村上浩紀編, 広川書店, pp. 60-76.
49. Kato, M., Mochizuki, K., Hashizume, S., Tachibana, H., Shirahata, S. and Murakami, H. (1993) Activity enhancement of a lung cancer-associated human monoclonal antibody HB4C5 by N-deglycosylation. Hum. Antibod. Hybridomas, 4: 9-14.
50. 橋爪秀一 (1993) ヒト型モノクローナル抗体の利用. 化学と生物, 31: 104-107.
51. Yasumoto, K., Setoguchi, Y., Kamei, M., Kato, M., Nomoto, K., Murakami, H. and Hashizume, S. (1993) Cancer-specific binding of a mouse MoAb vs. Candida krusei cytochrome c: an antigen recognized by a cancer-associated human MoAb HB4C5. Hum. Antibod. Hybridomas, 4: 186-189.
52. Hashizume, S., Sato, S., Kato, M., Kamei, M., Mochizuki, K., Kuroda, K., Kusakabe, K., Kanaya, K., Yasumoto, K., Nomoto, K. and Murakami, H. (1993) Application of human monoclonal antibodies to various clinical uses. In Proceedings of The Fourth Annual Meeting of Japanese Association for Animal cell Technology (eds. Kaminogawa S. et al.), pp. 641-646.
53. Matsuda, M., Kamei, M., Sugimoto, N. and Hashizume, S. (1993) Application of anti-tetanus human monoclonal antibodies. in Proceedings of The Fourth Annual Meeting of Japanese Association for Animal Cell Technology (eds. Kaminogawa S. et al.), pp. 617-623.
54. Mochizuki, K., Sato, S., Kato, M. and Hashizume, S. (1993) Enhanced production of human monoclonal antibodies by the use of fructose in serum-free hybridoma culture media. Cytotechnology, 13: 161-173.
55. Kusakabe, K., Kanaya, K., Sato, S., Kato, M., Mochizuki, K., Hashizume, S., Yasumoto, K., Murakami, H. and Nomoto, K. (1994) Accumulation enhancement of human monoclonal antibody HB4C5 to lung tumor xenografts by N-deglycosylation. J. Nucl. Med., 35: 289-295.
56. Hashizume, S., Sato, S., Kato, M., Kamei, M., Mochizuki, K., Kuroda, K., Kusakabe, K., Kanaya, K., Yasumoto, K., Nomoto, K. amd Murakami, H. (1994) Clinical applications of human monoclonal antibodies. in Animal Cell Technology: Basic & Applied Aspects (eds. Kobayashi T. et al.), Vol. 6, pp. 75-79.
57. Ikeda, T., Sai, M., Fujiwara, K., Honjoh, T. and Hashizume, S. (1994) Serum-free medium for normal human melanocytes. in Animal Cell Technology: Basic & Applied Aspects (eds. Kobayashi T. et al.), Vol. 6, pp. 345-349.
58. Shoji, M., Sato, S., Kamei, M., Kato, M., Hashizume, S., Seki, K., Yasumoto, K., Nagashima A., Nakahashi, H., Suzuki, T., Imai, T., Nomoto, K. and Murakami, H. (1994) Specific reactivity of a human monoclonal antibody AE6F4 against cancer cells in tissues and sputa from lung cancer patients. Hum. Antibod. Hybridomas, 5: 116-122.
59. Shoji, M., Kawamoto, S., Setoguchi, Y., Mochizuki, K., Honjoh, T., Kato, M., Hashizume, S., Yasumoto, K., Nagashima A., Nakahashi, H., Suzuki, T., Imai, T., Nomoto, K. and Murakami, H. (1994) The 14-3-3 protein as the antigen for lung cancer-associated human monoclonal antibody AE6F4. Hum. Antibod. Hybridomas, 5: 123-130.
60. 橋爪秀一 (1994) ヒトモノクローナル抗体の作製と加工. 免疫核医学, 9: 50-53.
61. Shoji, M., Kato, M. and Hashizume, S. (1995) Electrophoretic recovery of proteins from polyacrylamide gel. J. Chromatography A, 698: 145-162.
62. Kawamoto, S., Shoji, M., Setoguchi, Y., Kato, M., Hashizume, S., Ichikawa, A., Osada, K., Katakura, Y., Tachibana, H. and Murakami, H. (1995) Molecular cloning of the 31 kDa cytosolic phospholipase A2, as an antigen recognized by the lung cancer-specific human monoclonal antibody, AE6F4. Cytotechnology, 17: 103-108.
63. Tsukazaki, K., Kuroda, K., Mochizuki, K., Kubushiro, K., Fukuchi, T., Kato, M., Hashizume, S. and Nozawa, S. (1995) A human monoclonal antibody to carbohydrate moiety of carcinoembryonic antigen. Hum. Antibod. Hybridomas, 6: 145-152.
64. Setoguchi, Y., Kato, M., Shoji, M., Honjoh, T., Kamei, M., Sugitani, M., Sato, S., Hashizume, S., Hanagiri, T., Yoshimatsu, T., Nakanishi, K., Yasumoto, K., Nagashima, A., Nakahashi, H., Suzuki, T., Imai, T., Shirahata S. and Nomoto, K. (1995) Immunocytochemical detection of lung cancer cells with monoclonal antibodies to 14-3-3 proteins. Hum. Antibod. Hybridomas, 6: 137-144.
65. Inoue, Y., Kawamoto, S., Seki, K., Teruya, K., Mochizuki, K., Kato, M., Hashizume, S., et al. (1996) Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system. J. Ferment. Bioeng., 81: 466-469.
66. Inoue, Y., Lopez, L.B., Kawamoto, S., Arita, N., Teruya, K., Seki, K., Shoji, M., Kamei, M., Hashizume, S., et al. (1996) Production of recombinant human monoclonal antibody using ras-amplified BHK-21 cells in a protein-free medium. Biosci. Biotech. Biochem., 60: 811-817.
67. Shoji, M., Kawamoto, S., Seki, K., Teruya, K., Setoguchi, Y., Mochizuki, K., Kato, M., Hashizume, S., et al. (1996) Lung cancer-reacting human recombinant antibody AE6F4: potential usefulness in the sputum cytodiagnosis. Hum. Antibod. Hybridomas, 7: 27-36.
68. Yamaguchi, M., Shirai, Y., Inouye, Y., Shoji, M., Kamei, M., Hashizume, S. and Shirahata, S. (1997) Changes in monoclonal antibody productivity of recombinant BHK cells immobilized in collagen gel particles. Cytotechnology, 23: 5-12.
69. Haruta, H., Tachibana, H., Mochizuki, K., Hashizume, S., Kusakabe, K., Shirahata, S. and Murakami, H. (1997) Class-switching of the IgM type anti-adenocarcinoma human antibody HB4C5 into an IgG1 type resulted in the loss of the antigen binding ability. Human Antibodies, 8: 137-145.
70. Nakanishi, K., Hashizume, S., Kato, M., Honjoh, T., Setoguchi, Y. and Yasumoto, K. (1997) Elevated expression levels of the 14-3-3 family of proteins in lung cancer tissue. Human Antibodies, 8: 189-194.
71. Ichikawa, A., Tachibana, H., Kawamoto, S., Kamei, M., Honjoh, T., Hashizume, S. and Shirahata, S. (1997) Cytokeratin 8 and 19 as antigens recognized by adenocarcinoma-reactive human monoclonal antibody AE6F4. Human Antibodies, 8: 195-202.
72. Ichikawa, A., Katakura, Y., Teruya, K., Hashizume, S. Matsuda, T. and Shirahata, S. (1999) In vitro immunization of human peripheral blood lymphocytes with 14-16 kDa rice allergen proteins. in Animal Cell Technology: Basic & Applied Aspects (eds. Kitagawa Y. et al.), Vol. 10, 191-197.
73. Inoue, Y., Fujisawa, M., Kawamoto, S., Shoji, M., Hashizume, S. Katakura, Y., Fuji, M. and Shirahata, S. (1999) Vitamin A acetate for efficient production of monoclonal antibody by human-human hybridomas. in Animal Cell Technology: Basic & Applied Aspects (eds. Kitagawa Y. et al.), Vol. 10, 317-321.
74. Sato, S., Takahashi, T., Kamei, M. and Hashizume, S. (1999) New functions of cocoa (cacao beans). Foods & Food Ingredients Journal of Japan, 180: 71-76.
75. Nishimura, E., Mochizuki, K., Kato, M., Hashizume, S., Haruta, H., Shirahata, S., Suzuki, T., Nomoto, K., Kanaya, K. and Kusakabe, K. (1999) Recombinant light chain of human monoclonal antibody HB4C5 as a potentially useful lung cancer-targeting vehicle. Human Antibodies, 9: 111-124.
76. Inoue, Y., Kawamoto, S., Shoji, M., Hashizume, S. Teruya, K., Katakura, Y. and Shirahata, S. (1999) Protein-free culture of ras-amplified recombinant BHK-21 cells. in Animal Cell Technology: Basic & Applied Aspects (eds. Sasaki R. et al.), Vol. 11, 133-137.
77. Takahashi, T., Yaguchi, H., Yamaguchi, H., Osaki, T., Sato, S., Kamei, M., Hashizume, S. and Kamiya, S. (1999) Antibacterial effects of cacao mass on enterohemorrhagic Escherichia coli O157:H7. Journal of the Japanese Association for Infectious Diseases, 73: 694-701.
78. Matou, T., Tsutsumi, H., Kamei, M., Ito, R. and Hahsizume, S. (1999) New application of cocoa to entral feeding in intensive care patients. Bio Industry, 16: 49-56.
79. Sato, S., Taguchi, H., Yamaguchi, H., Osaki, T., Takahashi, T., Kamei, M., Hashizume, S. and Kamiya, S. (1999) The effect of cocoa extract on the growth, adhesion and colonization of Helicobacter pylori. Progress in Medicine, 19: 1207-1213.
80. 橋爪秀一（1999）ポリフェノールの化学的側面. 化学と教育, 日本化学会, 47:612-613.
81. Inoue, Y., Fujisawa, M., Kawamoto, S., Shoji, M., Hashizume, S., Fujii, M., Katakura, Y. and Shirahata, S. (1999) Effectiveness of vitamin A acetate for enhancing the production of lung cancer specific monoclonal antibodies. Cytotechnology, 31: 77-83.
82. Ichikawa, A., Katakura, Y., Teruya, K., Hashizume, S. and Shirahata, S. (1999) In vitro immunization of human peripheral blood lymphocytes: establishment of B cell lines secreting IgM specific for cholera toxin B subunit from lymphocytes stimulated with IL-2 and IL-4. Cytotechnology, 31: 131-139.
83. 橋爪秀一（2000）さびることから身体を守るポリフェノール. 理科教室, 新生出版, 43(4): 57, 43(5): 63, 43(6): 63.
84. 亀井優徳、望月克巳、橋爪秀一、奥田拓道（2001）グロビン蛋白分解物を含有するゼリー飲料摂取による食後血清トリグリセリド濃度の上昇抑制効果. 健康･栄養食品研究, 4: 1-11.
85. 亀井優徳、佐藤進、杉山謙吉、橋爪秀一（2001）ココアのヘリコバクターピロリ殺菌効果および臨床試験. Bio Industry, 18: 5-14.
86. Ichikawa, A., Shim S-Y., Katakura, Y., Teruya, K., Hashizume, S. and Shirahata, S. (2001) Molecular analysis of cross-reactive human monoclonal antibody AE6F4 generated by in vitro immunization: Epitope mapping of AE6F4 antibody on 14-3-3 family proteins and cytokeratin 8.Cytotechnology, 36: 101-107.
87. Kawahara, T., Ichikawa, A., Katakura, Y., Teruya, K., Yoshida, T., Kikuchi, M., Kamei, M., Hashizume, S. and Shirahata, S. (2001) Establishment of hybridomas producing cancer specific human antibodies from B cell line derived from PBL of a patient with adult T cell leukemia. Cytotechnology, 36: 171-177.
88. 神谷茂、大崎敬子、佐藤進、亀井優徳、橋爪秀一 (2002) ココアのHelicobacter pyloriに及ぼす効果. Helicobacter Research 6: 112-115.
89. 稲垣宏之、藤田尚孝、荒川久美子、杉山和久、橋爪秀一、奥田拓道 (2002) グロビン蛋白分解物含有の茶飲料摂取による脂肪摂取後血清トリグリセリド濃度の上昇抑制効果．健康・栄養食品研究, 5: 1-14.
90. 亀井優徳、吉川真理子、橋爪秀一 (2003) ココアの冷え性改善効果．食の科学, 2 (No. 300): 4-13.
91. Ono, K., Takahashi, T., Kamei, M., Mato, T., Hashizume, S., Kamiya, S. and Tsutsumi, H. (2003) Effects of an aqueous extract of cocoa on nitric oxide production of macrophages activated by lipopolysaccharide and interferon-γ. Basic Nutritional Investigation, 19: 681-685.
92. Masuda, Y., Haramizu, S., Oki, K., Ohnuki, K., Watanabe, T., Yazawa, S., Kawada, T., Hashizume, S. and Fushiki, T. (2003) Up-regulation of uncoupling proteins (UCPs) by oral administration of capsiate, a non-pungent capsaicin analog. J. Appl. Physiol., 95: 2408-
93. Iida, T., Moriyama, T., Kobata, K., Morita, A., Murayama, N., Hashizume, S., Fushiki, T., Yazawa, S., Watanabe, T. and Tominaga, M. (2003) TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology, 44: 958-967.
94. Zhao, H., Hashizume, S., Wang D., et al. (2003) A sandwich enzyme immunoassay for quantitative detection of IgG contents of anti-tetanus human monoclonal antibodies. 微生物学免疫学進展，31: 44-46.
95. Zhao H., Wang, D., Xiaojin, L., Hashizume, S. and Kamei, M. (2003) Neutralizing activity and preventive and curative effects of human MoAb to tetanus toxin. Chin. J. Biologicals, 16: 356-358.
96. Nishimura, E., Kato, M. and Hashizume, S. (2003) Human β-defensin-2 induction in human foreskin keratinocyte by synergetic stimulation with foods and Escherichia coli. Cytotechnology, 43: 135-144.
97. Hibi, M., Hachimura, S., Hashizume, S., Obata, T. and Kaminogawa, S. (2003) Amaranth grain inhibits antigen-specific IgE production through the augmentation of IFN-γresponse in vivo and in vitro. Cytotechnology, 43: 33-40.
98. Hibi, M., Hachimura, S., Somaya, T., Toda, E., Hashiguchi, M., Takayama, T., Sasaki, K., Senga, T., Hashizume, S. and Kaminogawa, S. (2003) Splenic dendritic cells from antigen-fed mice induced antigen-specific T cell unresponsiveness in vivo. Cytotechnology, 43: 41-48.
99. Hibi, M., Hachimura, S., Ise, W., Sato,A., Yoshida, T., Takayama, T., Sasaki, K., Senga, T., Hashizume, S., Totsuka, M. and Kaminogawa, S. (2003) Dendritic cells from spleen, mesenteric lymph node and Peyer’s patch can induce both production of IL-4 and IFN-γof naïve CD4+ T cells in their primary culture, depending on antigen doses. Cytotechnology, 43: 49-55.
100. 神谷茂, 大崎敬子, 佐藤進, 高橋俊雄, 亀井優徳, 橋爪秀一 (2004) 病原細菌に及ぼす効果. チョコレート･ココアの科学と機能, 福場博保他編, アイ･ケイコーポレーション, pp. 119-131.
101. Nishimura, E., Eto, A., Kato, M., Hashizume, S., Imai, S., Nisizawa, T. and Hanada, N. (2004) Oral streptococci exhibit diverse susceptibility to human β-defensin-2: Antimicrobial effects of hBD-2 on oral streptococci. Current Microbiology, 48: 85-87.
102. Matsui, N., Ito, R., Nishimura, E., Yoshikawa, M., Kato, M., Kamei, M., Shibata, H., Matsumoto, I., Abe, K. and Hashizume, S. (2005) Ingested cocoa can prevent high-fat diet-induced obesity by regulating the expression of genes for fatty acid metabolism. Nutrition, 21: 594-601.
103. 油谷賢一、小山由利子、渡邊恵理子、渡邉由美子、本庄勉、橋爪秀一 (2006) モリナガFASPEK特定原材料測定キットを用いた食物アレルギー物質を含む食品素材の検出. アレルギーの臨床, 26(6): 72(472)-77(477).
104. 橋爪秀一 (2007) 食物アレルゲンの検出技術と課題．食の安全を担う科学研究の新たな展開, 食の安全研究センター設立記念シンポジウム組織委員会・編, 東京大学, pp. 75-83.
105. Hashizume, S. and Kawahara, H. (2007) Inducing of human IgE antibodies by in vitro immunization. in Proceedings of the 20th ESACT Meeting (Dresden), in press.
106. Hashizume, S., Kawano, K., Katsuragawa, H., Kokubo, H., Yamamoto, M., Kamada, A. and Watanabe, T. (2008) Does Taichi-quan reduce psychosomatic stress? J. Intl. Soc. Life Info. Sci., 26: 129-133.
107. Katsuragawa H., Kawano, K., Kokubo, H., Yamamoto, M., Hashizume, S., Kamada, A. and Watanabe, T. (2008) Experiments on scientific resolution of Taichi-quan practice. J. Intl. Soc. Life Info. Sci., 26: 123.
108. Kawano, K., Katsuragawa, H., Kokubo, H., Yamamoto, M., Hashizume, S., Kamada, A. and Watanabe, T. (2008) Changes in EEGs during Taichi-quan. J. Intl. Soc. Life Info. Sci., 26: 124-128.
109. Kokubo, H., Yamamoto, M., Katsuragawa, H., Kamada, A., Kawano, K., Hashizume, S. and Watanabe, T. (2008) Research on brain blood flow during Taichi-Quan by using fNIRS. J. Intl. Soc. Life Info. Sci., 26: 134-137.
110. Kamada, A., Kawano, K., Katsuragawa, H., Kokubo, H., Yamamoto, M., Hashizume, S. and Watanabe, T. (2008) The change of pupillogram by Taichi-quan. J. Intl. Soc. Life Info. Sci., 26: 138-145.
111. Hashizume, S. (2008) Effect of various foods on stress reduction. J. Intl. Soc. Life Info. Sci., 26(2): 208-212.
112. Maruyama, S., Hashizume, S., Tanji, T., Yamada, K. and Tachibana, H. (2008) Cistanche salsa extract enhanced antibody production in human lymph node lymphocytes. Pharmacologyonline, 2: 341-348.
113. Hashizume, S., Kamada, A., Kawano, K., Kokubo, H., Yamamoto, M., Katsuragawa, H. and Watanabe, T. (2009) Stamping on an uneven floor mat leads to stress reduction. J. Intl. Soc. Life Info. Sci., 27: 73-77.
114. Kawano, K., Sakaue, Y., Katsuragawa, H., Takagi O., Kokubo, H., Hashizume, S., Kamada, A., Yamamoto, M. and Watanabe, T. (2009) Changes in EEGs during Taichi-quan: Part II. J. Intl. Soc. Life Info. Sci., 27: 189-193.
115. Hashizume, S. (2010) Stress-reducing activity of various food ingredients. J. Intl. Soc. Life Info. Sci., 28: 148-152.
116. Kamada, A., Takagi, O., Kawano, K., Kokubo, H., Hashizume, S., Katsuragawa, H., Yamamoto, M. and Watanabe, T. (2010) Changes of papillary light response and electrodermal activity (EDA) while doing Taichi-quan. J. Intl. Soc. Life Info. Sci., 28: 154-160.
http://idea-cl.com